Scott L Friedman Selected Research

Non-alcoholic Fatty Liver Disease

10/2023	Long-term exposure to air pollution and prevalent nonalcoholic fatty liver disease.
1/2023	An autocrine signaling circuit in hepatic stellate cells underlies advanced fibrosis in nonalcoholic steatohepatitis.
1/2022	Molecular Signature Predictive of Long-Term Liver Fibrosis Progression to Inform Antifibrotic Drug Development.
1/2021	Mechanisms and disease consequences of nonalcoholic fatty liver disease.
7/2020	Prevalence and Profile of Nonalcoholic Fatty Liver Disease in Lean Adults: Systematic Review and Meta-Analysis.
1/2018	Current and future therapeutic regimens for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.
1/2018	A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis.
1/2018	Diagnostic modalities for nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and associated fibrosis.
11/2016	Nonalcoholic Steatohepatitis Is Associated With Increased Mortality in Obese Patients Undergoing Bariatric Surgery.
4/2016	The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation.

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Scott L Friedman Research Topics

Disease

101	Fibrosis (Cirrhosis) 04/2024 - 01/2002
48	Liver Cirrhosis (Hepatic Cirrhosis) 01/2024 - 08/2004
46	Neoplasms (Cancer) 11/2021 - 03/2003
31	Liver Diseases (Liver Disease) 01/2023 - 02/2003
28	Hepatocellular Carcinoma (Hepatoma) 11/2021 - 02/2002
25	Inflammation (Inflammations) 04/2024 - 06/2004
21	Non-alcoholic Fatty Liver Disease 10/2023 - 12/2004
11	Infections 01/2020 - 02/2002
10	Fatty Liver 01/2024 - 05/2013
8	Cicatrix (Scar) 06/2021 - 07/2002
8	Necrosis 01/2016 - 12/2004
7	Alcoholic Fatty Liver 10/2023 - 05/2015
7	Hepatitis C 07/2014 - 12/2004
6	Liver Neoplasms (Liver Cancer) 10/2023 - 12/2008
6	Carcinogenesis 11/2019 - 01/2005
6	Prostatic Neoplasms (Prostate Cancer) 02/2006 - 04/2004
4	Neoplasm Metastasis (Metastasis) 10/2023 - 03/2003
3	Insulin Resistance 04/2024 - 04/2012
3	Disease Progression 01/2024 - 01/2012
3	Portal Hypertension 12/2022 - 09/2013
3	Chronic Hepatitis C 11/2017 - 08/2007
3	Vascular System Injuries 04/2016 - 04/2009
2	Proteinuria 12/2023 - 09/2018
2	Obesity 01/2023 - 02/2010
2	Hypoxia (Hypoxemia) 11/2019 - 03/2003
2	Wounds and Injuries (Trauma) 04/2016 - 02/2011

Drug/Important Bio-Agent (IBA)

28	Proteins (Proteins, Gene)FDA Link 03/2024 - 07/2002
21	CollagenIBA 04/2024 - 04/2002
16	Biomarkers (Surrogate Marker)IBA 01/2022 - 11/2007
16	Messenger RNA (mRNA)IBA 04/2016 - 03/2003
13	Transcription Factors (Transcription Factor)IBA 01/2020 - 08/2004
12	Carbon Tetrachloride (Tetrachloromethane)IBA 01/2024 - 07/2006
11	Kruppel-Like Factor 6IBA 02/2013 - 04/2004
9	CytokinesIBA 01/2021 - 07/2002
7	Thioacetamide (Thioacetamid)IBA 06/2018 - 08/2006
7	Protein Isoforms (Isoforms)IBA 02/2013 - 02/2005
6	Transforming Growth Factors (Transforming Growth Factor)IBA 03/2024 - 09/2004
6	Collagen Type I (Type I Collagen)IBA 03/2024 - 03/2007
6	Antiviral Agents (Antivirals)IBA 01/2023 - 07/2014
6	Bile Acids and Salts (Bile Acids)IBA 06/2021 - 04/2013
6	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/2013 - 03/2003
5	LipidsIBA 12/2023 - 05/2013
5	LigandsIBA 01/2023 - 02/2002
5	MicroRNAs (MicroRNA)IBA 01/2022 - 05/2011
5	CholesterolIBA 11/2021 - 04/2016
5	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 04/2012
5	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 04/2004
5	Transforming Growth Factor beta (TGF-beta)IBA 04/2016 - 05/2007
5	Sorafenib (BAY 43-9006)FDA Link 03/2013 - 10/2009
4	Insulin (Novolin)FDA Link 04/2024 - 04/2012
4	Vitamin A (Retinol)FDA LinkGeneric 07/2017 - 04/2004
4	Matrix Metalloproteinases (MMPs)IBA 04/2016 - 09/2010
4	3,7,11,15- tetramethyl- 2,4,6,10,14- hexadecapentaenoic acidIBA 05/2004 - 11/2002
3	FructoseIBA 01/2024 - 01/2018
3	EnzymesIBA 01/2023 - 04/2013
3	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2023 - 02/2007
3	cenicrivirocIBA 01/2022 - 01/2016
3	Interleukin-6 (Interleukin 6)IBA 02/2021 - 04/2005
3	Extracellular Matrix ProteinsIBA 11/2019 - 10/2015
3	Diethylnitrosamine (N-Nitrosodiethylamine)IBA 11/2019 - 10/2012
3	nasIBA 01/2018 - 04/2013
3	InterferonsIBA 11/2017 - 05/2004
3	Peptide Hydrolases (Proteases)FDA Link 04/2015 - 02/2003
3	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2013 - 02/2002
3	Interleukin-10 (Interleukin 10)IBA 11/2012 - 09/2004
3	Discoidin Domain Receptor 2IBA 10/2012 - 02/2011
3	Reactive Oxygen Species (Oxygen Radicals)IBA 08/2012 - 02/2007
3	ChemokinesIBA 01/2012 - 08/2010
3	alpha-Fetoproteins (alpha-Fetoprotein)IBA 09/2009 - 04/2004
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2009 - 12/2004
3	Small Interfering RNA (siRNA)IBA 12/2008 - 07/2005
3	Oxidants (Oxidizing Agents)IBA 12/2004 - 01/2002
3	RetinoidsIBA 05/2004 - 11/2002
2	Actins (F Actin)IBA 03/2024 - 05/2007
2	Mannose (D-Mannose)IBA 01/2024 - 12/2019
2	4-(3-chlorophenylsulfanyl)piperidineIBA 12/2022 - 11/2022
2	Aspartate Aminotransferases (Aspartate Transaminase)IBA 11/2022 - 01/2013
2	Hormones (Hormone)IBA 11/2021 - 08/2008
2	obeticholic acidIBA 10/2021 - 11/2020
2	Fatty Acids (Saturated Fatty Acids)IBA 10/2021 - 06/2021
2	InterleukinsIBA 02/2021 - 11/2012
2	Interferon-gamma (Interferon, gamma)IBA 11/2019 - 07/2009
2	Hydroxyproline (4 Hydroxyproline)IBA 09/2018 - 01/2015
2	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 09/2018 - 12/2008
2	CreatinineIBA 09/2018 - 01/2016
2	Urea (Carbamide)FDA LinkGeneric 09/2018 - 01/2016
2	NitrogenIBA 09/2018 - 01/2016
2	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 09/2018 - 07/2015
2	Chemokine ReceptorsIBA 01/2018 - 01/2012
2	IntegrinsIBA 11/2017 - 01/2016
2	Ribavirin (Virazole)FDA LinkGeneric 11/2017 - 08/2007
2	Activin Receptors (Activin Receptor)IBA 04/2016 - 01/2013
2	EndoglinIBA 04/2016 - 04/2009
2	Metalloproteases (Metalloproteinases)IBA 04/2016 - 04/2015

Therapy/Procedure

57	Therapeutics 03/2024 - 02/2003
9	Liver Transplantation 12/2023 - 02/2003
4	Chemoprevention 01/2018 - 04/2004
3	Drug Therapy (Chemotherapy) 01/2021 - 04/2004
3	Bariatric Surgery 01/2018 - 04/2013
3	Ligation 07/2015 - 09/2011